STOP-AS : Search Treatment and improve Outcome for Patient with Aortic Stenosis

The STOP-AS project is a research project which has been laureate of the second University Hospital Research (RHU) call for project.

Supported by the University Hospital Federation (FHU) REMOD-VHF (Early Markers of Cardiovascular Remodeling in Valvulopathy and Heart Failure) and coordinated by Professor Hélène Ektchaninoff, head of the Cardiology Department of the University Hospital of Rouen, this project aims to improve knowledge of aortic stenosis (AS) and develop new therapies.

Aortic stenosis (AS) affects more than 2% of the elderly population in western countries, that is much as Alzheimer disease. Due to the aging of the population, this percentage wil double or even triple in the next 50 years. Symptomatic aortic stenosis is a fatal disease: without intervention, 1 in 5 people will die within 2 years. Currently, the treatment consists of surgical (SVR) or percutaneous valve replacement (TAVR).
The objectices of the STOP-AS project are to understand the mechanisms of the aortic stenosis and its progression in order to develop new therapeutics to characterize left ventricle remodeling associated with AS before and after aortic valve replacement (SVR or TAVR) and to evaluate the medical-economic impact of TAVR extending to all AS patients (SVR is heavier and more expensive).
This consortium of 15 partners (11 academic partners and 4 industrial partners) will improve knowledge on AS and offer the most appropriate care to patient.
All of this will be possible thankds to pre-clinical studies, multicenter trials and national registries as welle as innovative approached to imaging, biomarkers and non-invasive ultrasound-based treatments.

Consortium STOP AS

RHU STOP-AS consortium

FHU REMODVHF - Mentions légales à faire - Création Internet Bordeaux